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Title: NORMAL MACULAR THICKNESS BASED ON OPTICAL COHERENCE TOMOGRAPHY AND ITS DETERMINANTS AMONG BLACK ADULTS(2018)

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Background The retina is the innermost layer of the eye and is divided into two regions: posterior pole and peripheral retina. The posterior pole of the retina consists of the macula and the optic disc. The macula is located temporal to the optic disc and is about 6 mm in diameter. The central depressed part of the macula is the fovea. This is the most sensitive part of the retina and is responsible for high perception of vision. Optical coherence tomography (OCT) is a non- invasive imaging modality that provides high-resolution quantitative measurements of the retinal thickness. Despite the fact that OCT has become a reliable tool for detecting and quantifying small changes in macular thickness, some studies showed significant variations in macular thickness among normal subjects by ethnicity, age and gender. Objective To determine normal macular thickness using OCT and its determinants among black adults attending MURHEC, Southwestern Uganda. Methods This was a hospital-based descriptive cross sectional study. We enrolled 150 subjects with best corrected visual acuity of 6/6 or better with and without any history or evidence of pathological features of the retina, between August and September 2017. We collected data on socio- demographic characteristics, visual acuity, refraction, anterior segment examination, fundoscopy and macular thickness using Cirrus SD-OCT. All data were entered into EP.INFO software and then imported into STATA 13.0 software for analysis. Results The participants’ ages ranged from 18 to 79 years; 57% were females. The mean fovea thickness for all subjects was 231.1 ± 20.2 μm (Mean ± sd). The overall average macular thickness (thickness average cube) in each of the 9 regions of the early treatment diabetic retinopathy study (ETDRS) was 272.7 ± 12.2 μm (Mean ± sd). We found significant variations of overall average macular thickness (thickness average cube) by age (P = 0.0015). Females were found to have thinner foveas compared to males (P = 0.0003). Conclusion We have provided normative data for macular thickness using OCT. Our study found tendency of decreasing of overall average macular thickness with increasing age, while fovea thickness is thinner in females, compared to males.

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